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以钛酸正丁酯(Cl6H36TiO4)为原料,采用溶胶-凝胶法制备了TiO2薄膜。TiO2薄膜分别在300,400,500,600,800℃下于空气中热处理2h。将热处理前后的TiO2薄膜浸泡于模拟体液(simulated body fluids,SBF)中,考察其表面诱导类骨磷灰石形成的能力。利用X射线衍射、扫描电子显微镜、能谱仪、Fourier变换红外光谱等测试手段表征TiO2薄膜和磷灰石的微观结构。结果表明:原始和经300℃热处理的TiO2薄膜为无定形结构;随着煅烧温度的升高,TiO2由无定形结构向锐钛矿相转变;温度升高至800℃后,锐钛矿相完全转化为金红石相。TiO2薄膜经SBF浸泡7d后,经400,500,600,800℃热处理的TiO2薄膜表面生成含有碳酸根的羟基磷灰石,且其Ca与P的摩尔比为1.52,接近人体骨骼的钙磷比(1.67)。而原始和经300℃热处理的TiO2薄膜无此现象发生,这说明TiO2薄膜的晶型对其生物活性具有重要影响,锐钛矿和金红石相TiO2薄膜均具有诱导磷灰石生成的能力。
Abstract：Titania (TiO2) thin films were deposited using tetrabutylorthotitanate (Cl6H36TiO4) as a starting material by a sol-gel method.The as-deposited TiO2 films were annealed at 300,400,500,600 and 800 ℃ for 2h in atmosphere,respectively.The as-deposited and annealed TiO2 films were soaked in simulated body fluids (SBF) to investigate the formation of bone-like apatite on the surfaces.The effect of anneal temperature on the phase composition and the bioactivity of TiO2 films were investigated by X-ray diffraction,scanning electron microscopy,energy-dispersive X-ray spectrometry and Fourier transform infrared spectroscopy.The results indicate that the as-deposited TiO2 film and TiO2 films annealed at 300 ℃ are amorphous.The phase compositions of TiO2 films transformed from anatase to rutile when the anneal temperature increased.The phase composition of TiO2 film annealed at 800 ℃ are mainly composed of rutile.The carbonate-containing hydroxyapatite could be induced on the surface of TiO2 film annealed at 400,500,600 ℃ and 800 ℃ during the SBF immersion test.However,the as-deposited TiO2 film and the TiO2 film annealed at 300 ℃ has no bioactivities.The bioactivity of the TiO2 film depends on the phase composition.The anatase and rutile formed in the films both possess an excellent bioactivity.
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基本信息:
DOI：10.14062/j.issn.0454-5648.2010.01.001
中图分类号:O614.411
引用信息:
[1]赵晓兵,游静,马丽,等.相组成对TiO_2薄膜生物活性的影响(英文)[J].硅酸盐学报,2010,38(01):148-152.DOI:10.14062/j.issn.0454-5648.2010.01.001.
基金信息:
江苏省自然科学基金(BK2008541)资助项目
2010-01-15
2010-01-15